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Histologic Examination of Mice Treated with rRp450
(A and E) H&E staining of BT-12 (A) and D425med (E) tumors demonstrates HSV inclusion bodies (arrows). (B–D and F–H) Immunohistochemical staining of brains from tumor-bearing mice shows strong focal expression of oHSV-1 in BT-12 (B and C), BT-16 (D), D425med (F and G), and D283med (H) cells. Staining is cytoplasmic and nuclear in location and is associated with tumor cell necrosis.
