TABLE 3.
T > MICa in plasma and interstitium of subcutaneous adipose tissue of septic patients and healthy subjects after administration of 2 g of cefpirome
| MIC (mg/liter) | Populationb | Plasma
|
Subcutisc
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| T > MIC range (%) | No. of subjects with T > MIC of:
|
T > MIC range (%) | No. of subjects with T > MIC of:
|
||||||
| <60% | 60-90% | >90% | <60% | 60-90% | >90% | ||||
| 4 | Septic | 100 | 0 | 0 | 11 | 90-100 | 0 | 1 | 7 |
| Healthy | 75-100 | 0 | 2 | 5 | 77-100 | 0 | 2 | 5 | |
| 8 | Septic | 81-100 | 0 | 1 | 10 | 55-100 | 1 | 1 | 6 |
| Healthy | 60-100 | 0 | 4 | 3 | 59-85 | 1 | 6 | 0 | |
| 16 | Septic | 57-100 | 1 | 3 | 7 | 13-100 | 2 | 2 | 4 |
| Healthy | 45-91 | 3 | 3 | 1 | 37-81 | 4 | 3 | 0 | |
a
T > MIC categories in percent refer to a dosing interval of 8 h.
b
Eleven septic patients and seven healthy subjects were tested.
c
Data for 3 of 11 patients were excluded from the T > MIC calculation, because the distribution from plasma to tissue was not completed within the observation period.