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. 2017 Jun 8;8:15502. doi: 10.1038/ncomms15502

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Copyright © 2017, The Author(s)

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(a) Survival of Znrf1^Δ (dotted line, n=11) and Znrf1^F/F mice (solid line, n=11) injected intraperitoneally with LPS (15 mg kg⁻¹ of body weight). (b) ELISA analysis of the indicated cytokines in sera from Znrf1^Δ and Znrf1^F/F mice 6 h after LPS challenge. (c) Survival of Znrf1^Δ mice (dotted line, n=8) and Znrf1^F/F mice (solid line, n=8) after CLP challenge. (d) ELISA analysis of the indicated cytokines in sera from Znrf1^Δ and Znrf1^F/F mice collected 0, 4 and 8 h after the CLP procedure. (e) Haematoxylin and eosin staining of histological sections of lung tissues collected from Znrf1^Δ and Znrf1^F/F mice (lower panel) 8 h after CLP and from sham-operated control mice (upper panel). Objective magnification, × 20. Scale bar, 20 μm. (f) The MPO activity in lung tissues from Znrf1^Δ and Znrf1^F/F mice 8 h after CLP. *P<0.05 (Student's t-test). (Error bars, s.d.).