Table 3.

Association of SBP category with all-cause mortality by frailty category, gender and anti-hypertensive treatment.

	SBP category (mm Hg)	‘Fit’		‘Mild frailty’		‘Moderate frailty’		‘Severe frailty’
		HR (95% CI)	P value	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
			Not Treated with Antihypertensive Medications
Men	<110	1.71 (1.42 to 2.05)	<0.001	1.96 (1.66 to 2.30)	<0.001	2.05 (1.69 to 2.47)	<0.001	1.78 (1.21 to 2.64)	0.004
	110-119	1.29 (1.13 to 1.47)	<0.001	1.47 (1.31 to 1.65)	<0.001	1.58 (1.36 to 1.84)	<0.001	1.39 (1.06 to 1.82)	0.015
	120-139	Reference		Reference		Reference		Reference
	140-159	0.83 (0.76 to 0.90)	<0.001	0.85 (0.78 to 0.92)	<0.001	0.88 (0.77 to 1.00)	0.052	1.28 (1.01 to 1.61)	0.039
	≥160	0.87 (0.76 to 0.99)	0.029	1.01 (0.87 to 1.17)	0.876	1.15 (0.91 to 1.46)	0.239	2.32 (1. 57 to 3. 45)	<0.001
Women	<110	1.63 (1.35 to 1.95)	<0.001	1.61 (1.38 to 1.88)	<0.001	2.11 (1.77 to 2.53)	<0.001	2.00 (1.55 to 2.58)	<0.001
	110-119	1.26 (1.10 to 1.44)	0.001	1.24 (1.12 to 1.39)	<0.001	1.43 (1.25 to 1.64)	<0.001	1.47 (1.20 to 1.82)	<0.001
	120-139	Reference		Reference		Reference		Reference
	140-159	0.73 (0.67 to 0.80)	<0.001	0.80 (0.74 to 0.87)	<0.001	0.90 (0.82 to 0.99)	0.039	0.85 (0.72 to 1.01)	0.062
	≥160	0.82 (0.72 to 0.92)	0.001	0.81 (0.72 to 0.92)	0.001	0.93 (0.79 to 1.11)	0.423	0.79 (0.56 to 1.11)	0.176
			Treated with Antihypertensive Medications
Men	<110	2.02 (1.54 to 2.66)	<0.001	2.51 (2,16 to 2.91)	<0.001	2.00 (1.71 to 2.33)	<0.001	1.62 (1.25 to 2.09)	<0.001
	110-119	1.54 (1.30 to 1.83)	<0.001	1.45 (1.32 to 1.60)	<0.001	1.44 (1.29 to 1.61)	<0.001	1.31 (1.11 to 1.53)	0.001
	120-139	Reference		Reference		Reference		Reference
	140-159	0.78 (0.71 to 0.85)	<0.001	0.83 (0.78 to 0.88)	<0.001	0.89 (0.82 to 0.96)	0.004	0.89 (0.77 to 1.03)	0.112
	≥160	0.98 (0.85 to 1.13)	0.748	1.04 (0.94 to 1.16)	0.436	1.18 (1.01 to 1.37)	0.028	1.21 (0.90 to 1.63)	0.212
Women	<110	1.86 (1.39 to 2.47)	<0.001	1.98 (1.67 to 2.35)	<0.001	2.34 (1.98 to 2.77)	<0.001	1.98 (1.53 to 2.56)	<0.001
	110-119	1.48 (1.23 to 1.79)	<0.001	1.46 (1.30 to 1.63)	<0.001	1.55 (1.38 to 1.75)	<0.001	1.44 (1.24 to 1.70)	<0.001
	120-139	Reference		Reference		Reference		Reference
	140-159	0.76 (0.70 to 0.84)	<0.001	0.79 (0.74 to 0.84)	<0.001	0.81 (0.75 to 0.87)	<0.001	0.80 (0.72 to 0.89)	<0.004
	≥160	0.85 (0.75 to 0.96)	0.011	0.91 (0.83 to 1.00)	0.068	0.95 (0.86 to 1.06)	0.401	0.97 (0.82 to 1.15)	0.733

Figures are hazard ratios (HR) and 95% confidence intervals adjusted for age, diastolic blood pressure, comorbidity, total cholesterol, smoking and anti-hypertensive treatment.