Table 13.

Neonatal AKI KDIGO classification [reprinted with permission from 136]

Stage	Serum creatinine	Urine output
0	No change in serum creatinine or rise <0.3 mg/dL	≥0.5 mL/kg/h
1	Serum creatinine rise ≥0.3 mg/dL within 48 h or serum creatinine rise ≥1.5 – 1.9 × reference serum creatinine1 within 7 days	<0.5 mL/kg/h for 6 – 12 h
2	Serum creatinine rise ≥2.0 – 2.9 × reference serum creatinine1	<0.5 mL/kg/h for ≥12 h
3	Serum creatinine rise ≥3.0 × reference serum creatinine1 or serum creatinine ≥2.5 mg/dL2 or receipt of dialysis	<0.3 mL/kg/h for ≥24 h or anuria for ≥12 h

Differences between the proposed neonatal AKI definition and KDIGO include the following:

¹Reference serum creatinine will be defined as the lowest previous serum creatinine value.

²Serum creatinine value of 2.5 mg/dL represents <10 mL/min/1.73 m².