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. Author manuscript; available in PMC: 2017 Jun 15.
Published in final edited form as: Curr Opin Genet Dev. 2014 Jul 15;26:66–72. doi: 10.1016/j.gde.2014.06.003

Figure 3.

Figure 3

Nutrient sensors ‘sense’ the environmental conditions that modulate the circadian clock and the aging process. Healthy environment, such as enough sleeping time and low caloric diet/scheduled feeding, modulates nutrient sensors localized in the brain and peripheral tissues. These in turn synchronize the circadian clocks. As a consequence, the activation of anti-aging mechanisms improves the homeostasis at different levels promoting healthy aging. The different physiological conditions might decelerate or accelerate aging.