Extended Data Figure 2. Metabolomic profiling of KL and K cancer cells and human NSCLC.

Left, Relative abundance of metabolites extracted from five KL (H157, A549, H460, H2122, H1355) and five K cell lines (Calu-1, Calu-6, H1373, H358, H441). Peak areas of each metabolite were normalized by total ion count (TIC) and the heat map displays the average value for each metabolite; n=4 independent cultures for each cell line. The color reflects a log₂ scale. Right, Relative abundance of metabolites extracted from four KL human tumors (Tumors 5, 8, 9 and 11-KL) and seven K human tumors (Tumors 1, 2, 3, 4, 6, 7 and 10-K). Peak areas of each metabolite were normalized by total ion count (TIC) followed by mean normalization and the heat map displays the average value for each metabolite; n=3 independent fragments for each tumor except Tumor 2-K (n=6), Tumor 8-KL (n=6) and Tumor 1-K (n=9). The color reflects a log₂ scale.