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. Author manuscript; available in PMC: 2018 May 18.
Published in final edited form as: Cell Chem Biol. 2017 Apr 13;24(5):565–575.e4. doi: 10.1016/j.chembiol.2017.03.013

Figure 1. Platinum complexes act as antidotes to cyanide poisoning by binding the cyanide anion.

Figure 1

Chemical structure of A) cisplatin, B) carboplatin, and C) hydroxocobalamin. Compounds were dissolved in DMSO for the assays in this figure. D) The effects of compounds on the survival of zebrafish exposed to 100 μM KCN. E) UV-VIS spectral shift data demonstrating the binding of the cisplatin to cyanide. F) Plot of the change in absorbance of 1 mM cisplatin over increasing concentrations of cyanide. G) Analysis by mass spectrometry demonstrates that cisplatin binds 4 cyanide anions. Also see Table S1.