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SPR sensorgrams showing the interaction of 14 (A) and 12 (B) to WT BACE1 before (red curve) and after (green curve) OM99-2 injection. (C) Sensorgrams of the binding of 12 (green curve) and 14 (red curve) to the BACE1 D32N mutant. The compounds were tested in CR series (0.03, 0.06, 0.13, 0.25, 0.50 mM).
