Table 1. Clinical characteristics of IFN−/DAA group, and comparison of cases stratified by early-emerging HCC.
| Variables | Total | Post-treatment Early-emerging HCC | ||
|---|---|---|---|---|
| No | Yes | P (uni) | ||
| n (%) | 101 | 89(88) | 12(12) | – |
| Age, years | 67 [24–85] | 67 [24–85] | 79 [50–82] | 0.19 |
| ≧65 yrs, n (%) | 62(62) | 53(60) | 9(75) | 0.36 |
| Sex (M: F), n (%) | 38(38): 63(62) | 35(37): 54(53) | 3(25): 9(75) | 0.53 |
| Pre-treatment parameters | ||||
| ALT, IU/L | 44[13–284] | 44[13–284] | 45[23–83] | 0.97 |
| AST, IU/L | 49[19–246] | 48[19–246] | 73[20–129] | 0.22 |
| G-GTP, IU/L | 31[11–268] | 32[11–268] | 30[18–79] | 0.92 |
| T-Bil, mg/dl | 0.8[0.3–2.7] | 0.8[0.3–2.7] | 1.1[0.4–2.0] | 0.0171* |
| Albumin, g/dl | 4.3[3.3–4.9] | 4.4[3–4.9] | 3.8[3.3–4.3] | 0.0002** |
| Platelet, 103/μl | 136[33–457] | 145[33–457] | 93[37–172] | 0.007** |
| PT-INR | 1.00[0.86–1.30] | 1.00[0.86–1.30] | 1.07[1.00–1.29] | 0.0003** |
| 4COL7s, ng/ml | 6.7[3.4–17] | 6.4[3.4–15] | 9[5.1–17] | 0.001** |
| AFP, ng/ml | 6[1–685] | 5[1–685] | 17.5[3–171] | 0.002* |
| HCV-RNA, LogIU/ml | 6.3[3.5–7.5] | 6.3[3.5–7.5] | 6.0 [5.3–7.1] | 0.25 |
| Total cholesterol, mg/dl | 159[107–241] | 161[107–241] | 133[110–184] | 0.013* |
| Forns index | 7.6[2.5–13] | 7.5[2.5–13] | 9.2[6.8–13] | 0.001** |
| <4.2, n (%) | 6(6) | 6(7) | 0(0) | 1.00 |
| FIB-4 | 3.87 [0.62–107] | 3.58 [0.62–107] | 10.14 [1.41–16.56] | 0.002** |
| >3.25, n (%) | 61(60) | 50(56) | 11(92) | 0.03* |
| APRI | 1.11[0.13–52] | 1.00[0.13–52] | 3.18[0.33–5.4] | 0.007** |
| >2.0, n (%) | 26(26) | 18(20) | 8(67) | 0.002** |
| Previous HCC, n (%) | 16(16) | 8(9) | 8(67) | <0.0001** |
| Previous IFN-combined, n (%) | 43(43) | 40(45) | 3(25) | 0.23 |
| DAA type, n (%) | 0.75 | |||
| DCV/ASV | 62(61) | 55(62) | 7(58) | |
| SOF/LDV | 39(38) | 34(38) | 5(42) | |
| NKG2D, % | 23.4 [1–71] | 22 [1–53] | 33[19–71] | 0.006** |
| Post-treatment parameters | ||||
| SVR, n (%) | 98(97) | 88(99) | 10(83) | 0.04* |
*, P< 0.05
**, P< 0.01.
Data are shown as median with the range within brackets. Abbreviations: 4COL7s: type 4 collagen 7s domain; AFP: alpha-fetoprotein; ASV: asunaprevir; CI: confidence interval; DAA: direct-acting agent; DCV: daclatasvir; F: female; G-GTP, gamma- glutamyl transpeptidase; HCC: hepatocellular carcinoma; HCV: hepatitis C virus; IFN: interferon; LDV: ledipasvir; M: male; SOF: sofosbuvir; SVR: sustained viral response; T-Bil, total bilirubin; uni: univariate.