Figure 5.

Itching responders: treatment differences in proportion of responders at 24 hour duration of action CAC or CAC 24 hours post treatment.

Notes: *P<0.0001 overall and at all other time points versus vehicle; **P=0.4142 at onset of action; ***P=0.0012 at 24 hours of CAC versus olopatadine 0.2%. The differences in least squares means for proportion of ocular itching responders between olopatadine 0.77% and vehicle at onset and 24 hours (P<0.0001) and between olopatadine 0.77% and olopatadine 0.2% at 24 hours (P=0.0012) were significant. A responder was defined as a patient with zero itch (a score of 0 on ocular itching for both the eyes) or with at least a 2-unit reduction in ocular itching relative to a baseline score. Two subjects (one in olopatadine 0.77% group, one in vehicle group) had missing data and were considered as nonresponders in this analysis. Ocular itching score was averaged across both the eyes and over the three post-CAC assessments (3, 5, and 7 minutes) for the calculation of unit reduction.

Abbreviation: CAC, conjunctival allergen challenge.