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. 2017 Jun 7;11:1681–1692. doi: 10.2147/DDDT.S135084

Table 2.

FIN solubility (S0), slope, correlation coefficient (R), stability constant (Kc), and CE from phase solubility diagrams

System S0 (mM) Slope R Kc (mM−1) CE
FIN/β-CyD 0.264 0.017 0.818 0.066 0.0173
FIN/HP-β-CyD 0.267 0.178 0.996 0.811 0.217
FIN/CM-β-CyD 0.116 0.169 0.997 1.753 0.203
FIN/SBE-β-CyD 0.206 0.200 0.998 1.213 0.250
FIN/DM-β-CyD 0.248 0.322 0.998 1.915 0.475

Abbreviations: FIN, finasteride; CE, complexation efficiency; β-CyD, β-cyclodextrin; HP-β-CyD, hydroxypropyl-β-CyD; CM-β-CyD, carboxymethyl-β-cyclodextrin; SBE-β-CyD, sulfobutyl ether-β-cyclodextrin; DM-β-CyD, dimethyl-β-cyclodextrin.