Figure 2.

Fezf1 and Fezf2 expression during embryogenesis. A: At E10.5 Fezf1 is expressed in progenitor cells in the forebrain and olfactory pit. Fezf2 is also expressed in forebrain progenitor cells; however within the olfactory pit its expression is restricted to the future VNO. B: By late gestation (E15.5), Fezf1 expression remains within the olfactory epithelium, but is absent from the cerebral cortex, and is decreasing within the VNO. In addition, it is expressed within the developing amygdala and hypothalamus. In contrast, Fezf2 expression remains high within the developing VNO and cerebral cortex. Within the cerebral cortex, Fezf2 is expressed at high levels in deep-layer postmitotic neurons and at a lower level in progenitor cells. Fezf2 is also expressed in the hypothalamus. C: At birth, expression of Fezf1 and Fezf2 largely mimics that at E15.5. Within the VNO, expression of Fezf2 has become restricted to the sustantacular cell layer. Within the cerebral cortex it maintains a high expression level in L5 SCPNs and lower levels in L6 CThPNs. Green represents Fezf1 expression, while purple represents Fezf2 expression.