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Fezf1 and Fezf2 functions during forebrain neurogenesis. A: Loss of both Fezf1 and Fezf2 during early forebrain neurogenesis results in an increase in HES5 expression. This leads to decreased neurogenesis and intermediate progenitor generation and decreases in the number of deep-layer projection neurons at birth. B: Fezf2 is expressed in multipotent RGCs that sequentially generate all major cortical projection neuron subtypes and glia.
