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. Author manuscript; available in PMC: 2017 Jul 9.
Published in final edited form as: Oncogene. 2017 Jan 9;36(24):3406–3416. doi: 10.1038/onc.2016.484

Figure 5. NgBR over-expression recapitulates the tumorigenesis function of Ras GTPases.

Figure 5

Over-expression of NgBR in NIH-3T3 cells causes transformation of NIH-3T3 cells. Images of colony formation of NIH-3T3-NgBR-HA cells (A) and quantification of the results (B) are shown. Data are represented as mean ± SEM (* P< 0.05, n=3). (C) High expression of NgBR in NIH-3T3 cells promotes tumorigenesis of NIH-3T3 cells. NIH-3T3 stable cell lines were subcutaneously implanted into the flank region of nude mice. Images of the nude mice were taken 5 weeks after cell implantation (n=8). (D) HE staining of normal skin tissues and NIH-3T3-NgBR-HA tumor tissues. NIH-3T3: NIH-3T3 cells containing the control empty vector. NIH-3T3-NgBR-HA: NIH-3T3 cells highly expressing NgBR-HA.