Table I.

Variables and parameters of the generalized multistage clonal expansion (MSCE) model

Variables
X(t)	Number of normal cells, treated deterministically or set to be constant X(t) = X
Yk(t)	Number of cells in initiated stage k
Z(t)	Number of malignant cells
Parameters
ν(t)	Per cell mutation rate for normal cells (asymmetric division)
μ0(t)	:= ν(t)X(t), a notational convenience
μk(t)	Mutation rate at the kth stage (asymmetric division)
αk(t)	Clonal expansion rate at the kth stage (symmetric division)
βk(t)	Cell death rate at the kth stage