Table 1.

Characteristics of 3,340 Patients With CF at the Time of Their First Stable Measurement of FEV₁ < 30%, 2003-2013

Age at eligibility, mean (SD), y	33.2 (10.1)
Female sex	1,444 (43.2)
Race, white vs nonwhite	3,220 (96.4)
FEV1 at eligibility, mean, SD (minimum-maximum), % predicted	25.6, 3.9 (4.3-29.9)
No. acute exacerbations/y, mean, SD (minimum-maximum)a	1.8, 1.7 (0-11)
Sputum culture positive
Pseudomonas aeruginosab	2,681 (80.3)
Burkholderia cepacia complexc	205 (6.1)
Nontuberculous mycobacteriumc	41 (1.2)
Supplemental oxygend	1,154 (34.6)
Noninvasive mechanical ventilatione	167 (5.0)
BMI at eligibility, mean (SD), kg/m2	20.4 (3.7)
BMI ≤ 18	721 (21.6)
CF-related diabetes in patients receiving insulinc	879 (26.3)
F508del mutation status
Homozygous F508del	1,427 (42.7)
Heterozygous F508del	1,106 (33.1)
Non-F508del	245 (7.3)
Unknownf	562 (16.8)
Pancreatic insufficiencyg	3,046 (91.2)
CF-related liver cirrhosis	91 (2.7)
Renal failure requiring dialysis	24 (0.7)
Osteoporosis	325 (9.7)
Pneumothorax requiring chest tubeh	74 (2.2)
Hemoptysish	100 (3.0)
Depression	769 (23.0)
Marital status
Married	1,253 (37.5)
Living together	228 (6.8)
High school graduate	2,719 (81.4)
Medicaid insurance	1,304 (39.0)

Data are presented as No. (%) unless indicated otherwise. Missing < 1% unless indicated otherwise. Covariate values are observed at the time of eligibility for the FEV₁ < 30% cohort unless indicated otherwise. CF = cystic fibrosis.

^aNumber of pulmonary exacerbations requiring IV antibiotics during the year prior to FEV₁ < 30%.

^bPseudomonas culture data missing for 172 (5.2%).

^cPositive if documented as present, otherwise recoded to negative.

^dSupplemental oxygen continuous or nocturnal.

^eNoninvasive mechanical ventilation data missing for 1,923 (57.6%).

^fMore than 75% of nongenotyped patients entered the cohort by 2007.

^gPancreatic insufficiency if patient was documented to take pancreatic enzymes.

^hDuring the year prior to eligibility.