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. 2017 Jan 20;151(6):1320–1328. doi: 10.1016/j.chest.2017.01.019

Table 1.

Characteristics of 3,340 Patients With CF at the Time of Their First Stable Measurement of FEV1 < 30%, 2003-2013

Age at eligibility, mean (SD), y 33.2 (10.1)
Female sex 1,444 (43.2)
Race, white vs nonwhite 3,220 (96.4)
FEV1 at eligibility, mean, SD (minimum-maximum), % predicted 25.6, 3.9 (4.3-29.9)
No. acute exacerbations/y, mean, SD (minimum-maximum)a 1.8, 1.7 (0-11)
Sputum culture positive
 Pseudomonas aeruginosab 2,681 (80.3)
 Burkholderia cepacia complexc 205 (6.1)
 Nontuberculous mycobacteriumc 41 (1.2)
Supplemental oxygend 1,154 (34.6)
Noninvasive mechanical ventilatione 167 (5.0)
BMI at eligibility, mean (SD), kg/m2 20.4 (3.7)
BMI ≤ 18 721 (21.6)
CF-related diabetes in patients receiving insulinc 879 (26.3)
F508del mutation status
 Homozygous F508del 1,427 (42.7)
 Heterozygous F508del 1,106 (33.1)
 Non-F508del 245 (7.3)
 Unknownf 562 (16.8)
Pancreatic insufficiencyg 3,046 (91.2)
CF-related liver cirrhosis 91 (2.7)
Renal failure requiring dialysis 24 (0.7)
Osteoporosis 325 (9.7)
Pneumothorax requiring chest tubeh 74 (2.2)
Hemoptysish 100 (3.0)
Depression 769 (23.0)
Marital status
 Married 1,253 (37.5)
 Living together 228 (6.8)
High school graduate 2,719 (81.4)
Medicaid insurance 1,304 (39.0)

Data are presented as No. (%) unless indicated otherwise. Missing < 1% unless indicated otherwise. Covariate values are observed at the time of eligibility for the FEV1 < 30% cohort unless indicated otherwise. CF = cystic fibrosis.

a

Number of pulmonary exacerbations requiring IV antibiotics during the year prior to FEV1 < 30%.

b

Pseudomonas culture data missing for 172 (5.2%).

c

Positive if documented as present, otherwise recoded to negative.

d

Supplemental oxygen continuous or nocturnal.

e

Noninvasive mechanical ventilation data missing for 1,923 (57.6%).

f

More than 75% of nongenotyped patients entered the cohort by 2007.

g

Pancreatic insufficiency if patient was documented to take pancreatic enzymes.

h

During the year prior to eligibility.