Table 4.

Multivariable Cox Proportional Hazards Regression Analysis of Predictors of Transplant-Free Survival in Patients With CF and FEV₁ < 30% Predicted^a

Covariate	HR (95% CI)	P Value
Female sex	1.55 (1.21-2.01)	.001
Height, in.	1.00 (0.97-1.04)	.796
BMI ≤ 18	1.57 (1.28-1.94)	< .001
F508del mutation status
Homozygousb	1.25 (0.84-1.85)	.273
Heterozygousb	1.19 (0.80-1.78)	.394
Unknownb	1.86 (1.21-2.84)	.004
One or more pulmonary exacerbationsc	1.71 (1.34-2.18)	< .001
Supplemental oxygend	2.08 (1.68-2.57)	< .001
Burkholderia cepaciae	1.81 (1.29-2.55)	.001
CFRD, receiving insulin	1.44 (1.17-1.79)	.001
ESRD, receiving dialysis	2.24 (0.76-6.56)	.141
Pneumothoraxf	0.98 (0.54-1.78)	.941
Hemoptysis	0.80 (0.45-1.42)	.445
Cirrhosis	1.10 (0.67-1.82)	.702
Osteoporosis	1.07 (0.78-1.46)	.671
Depression	1.15 (0.92-1.43)	.210
Medicaid insurance	1.16 (0.95-1.41)	.154
High school graduateg	1.05 (0.73-1.51)	.784
Marital status
Marriedh	0.71 (0.57-0.88)	.002
Living togetherh	0.86 (0.58-1.28)	.458
Global proportional hazards test		.8900

Statistically significant P values are shown in bold.

See Table 1 and 3 legends for expansion of abbreviations.

^aAnalysis adjusted for all covariates listed in the table; analysis stratified by calendar time and FEV₁ at baseline (in 5% increments) due to proportional hazards assumption violation.

^bReference group has no F508del mutations.

^cNumber of exacerbations requiring IV antibiotics in the year prior to FEV₁ < 30%, modeled as 1 or more exacerbations/y vs no exacerbations.

^dContinuous or nocturnal use of oxygen.

^eSputum infection with Burkholderia cepacia complex.

^fPneumothorax that required a chest tube.

^gHigh school graduate education or higher.

^hReference group is not married and not living with a partner.