Table 4.
Covariate | HR (95% CI) | P Value |
---|---|---|
Female sex | 1.55 (1.21-2.01) | .001 |
Height, in. | 1.00 (0.97-1.04) | .796 |
BMI ≤ 18 | 1.57 (1.28-1.94) | < .001 |
F508del mutation status | ||
Homozygousb | 1.25 (0.84-1.85) | .273 |
Heterozygousb | 1.19 (0.80-1.78) | .394 |
Unknownb | 1.86 (1.21-2.84) | .004 |
One or more pulmonary exacerbationsc | 1.71 (1.34-2.18) | < .001 |
Supplemental oxygend | 2.08 (1.68-2.57) | < .001 |
Burkholderia cepaciae | 1.81 (1.29-2.55) | .001 |
CFRD, receiving insulin | 1.44 (1.17-1.79) | .001 |
ESRD, receiving dialysis | 2.24 (0.76-6.56) | .141 |
Pneumothoraxf | 0.98 (0.54-1.78) | .941 |
Hemoptysis | 0.80 (0.45-1.42) | .445 |
Cirrhosis | 1.10 (0.67-1.82) | .702 |
Osteoporosis | 1.07 (0.78-1.46) | .671 |
Depression | 1.15 (0.92-1.43) | .210 |
Medicaid insurance | 1.16 (0.95-1.41) | .154 |
High school graduateg | 1.05 (0.73-1.51) | .784 |
Marital status | ||
Marriedh | 0.71 (0.57-0.88) | .002 |
Living togetherh | 0.86 (0.58-1.28) | .458 |
Global proportional hazards test | .8900 |
Statistically significant P values are shown in bold.
Analysis adjusted for all covariates listed in the table; analysis stratified by calendar time and FEV1 at baseline (in 5% increments) due to proportional hazards assumption violation.
Reference group has no F508del mutations.
Number of exacerbations requiring IV antibiotics in the year prior to FEV1 < 30%, modeled as 1 or more exacerbations/y vs no exacerbations.
Continuous or nocturnal use of oxygen.
Sputum infection with Burkholderia cepacia complex.
Pneumothorax that required a chest tube.
High school graduate education or higher.
Reference group is not married and not living with a partner.