Table 1.
Summary of Neural Innervation of Organs Affected in CF and Broadly Related Functions
| Major Organ | Innervation Affected in CF | Species | Bodily Function Controlled by Nervous System | Affected in CF | Species |
|---|---|---|---|---|---|
| Airways (trachea, bronchus, lungs) | + Pan et al72 Reznikov et al75 | Mouse, pig | Smooth muscle contraction Cough Submucosal gland secretion Respiration |
+ Cook et al45 Reznikov et al75 + Smith96 Hamutcu et al97 Smith et al98 Chang et al99 + Sun et al104 Ianowski et al107 Joo et al108 Salinas et al109 + Bonora et al83 Bureau et al84 Bongers et al85 |
Pig, mouse Human Mouse, pig, ferret, human Mouse, human |
| Intestines | + Wildhaber et al77 Collins et al78 | Human | Gastrointestinal motility | + Rogers et al103 Sun et al104 Zhou et al105 van der Doef et al106 | Human, mouse, pig, ferret |
| Sweat gland | + Heinz-Erian et al70 | Human | Sweating | + Cystic Fibrosis Foundation1 Wine25 | Human |
| Heart | Unknown | . . . | Heart rate | + Florencio et al79 Szollosi et al80 | Human |
| Pancreas | + Uc et al76 | Pig | Glucose regulation | + Moran et al111 Marshall et al112 Kerem et al113 Moran et al114 Yi et al115 Olivier et al116 | Human, pig, ferret |
| Gallbladder | Unknown | . . . | Gallbladder emptying | + Debray et al81 | Mouse |
| Reproductive tract | Unknown | . . . | Ovulation | + Johannesson et al82 | Human |
| Eye | Unknown | . . . | Pupillary constriction/dilatation | + Davis and Kaliner87 | Human |
| Skin | + Savage et al71 | Human | Skin wrinkling | + Grasemann et al91 Park et al92 Wilder-Smith93 | Human |
“+” means there are data to support the finding that the innervation or function is affected in CF. References listed directly support the finding that either innervation or bodily function controlled by the nervous system is affected in CF. CF = cystic fibrosis.