Table 1.
Comparison of various anthropometric and hormonal parameters between women with PCOS and controls.
| Parameters | Controls | PCOS | p value | ||
|---|---|---|---|---|---|
| Median | IQR | Median | IQR | ||
| Age (years) | 32.00 | 12.00 | 25.50 | 10.00 | 0.008* |
| BMI (kg/m2) | 25.00 | 6.20 | 33.00 | 10.50 | <0.001* |
| Waist Circumference (cm) | 78.00 | 15.00 | 101.00 | 23.30 | <0.001* |
| Hip Circumference (cm) | 101.00 | 15.50 | 116.00 | 19.30 | <0.001* |
| Salivary Testosterone (pmol/L) | 13.11 | 10.00 | 18.48 | 15.00 | <0.001* |
| Salivary Androstenedione (pmol/L) | 142.89 | 95.00 | 165.76 | 118.00 | 0.001* |
| Total Testosterone (nmol/L) | 1.00 | 0.50 | 1.25 | 0.70 | <0.001* |
| SHBG (nmol/L) | 44.00 | 26.00 | 27.00 | 22.00 | <0.001* |
| FAI | 2.27 | 2.04 | 4.26 | 4.71 | <0.001* |
| Androstenedione (nmol/L) | 7.40 | 5.90 | 40.31 | 7.90 | 0.001* |
| Salivary Testosterone/Androstenedione ratio | 0.08 | 0.05 | 0.10 | 0.07 | <0.001* |
| Serum Testosterone/Androstenedione ratio | 0.12 | 0.08 | 0.12 | 0.09 | 0.918 |
| Baseline Glucose (mmol/L) | 4.60 | 0.50 | 4.65 | 0.40 | 0.002 |
| 2 Hour Glucose (mmol/L) | 5.00 | 1.30 | 5.65 | 1.70 | <0.001* |
| Insulin (μIU/ml) | 6.40 | 4.08 | 13.75 | 11.69 | <0.001* |
| HOMA-IR | 1.34 | 0.98 | 2.86 | 2.47 | <0.001* |
BMI – Body Mass Index; FAI – Free Androgen Index; HOMA-IR – Homeostasis model of assessment – insulin resistance: IQR – inter quartile range. To convert values for glucose to milligrams per deciliter, divide by 0.056. To convert values for insulin to picomoles per liter, multiply by 6. To convert values for testosterone to nanograms per deciliter, divide by 0.03467. To convert values for SHBG to micrograms per deciliter, divide by 34.7. Demographics of the 175 subjects involved in the study, 65 women without PCOS and 110 women with PCOS. The diagnosis of PCOS was based on all three diagnostic criteria of the Rotterdam consensus, namely clinical and/or biochemical evidence of hyperandrogenemia (Ferriman-Gallwey score > 8; free androgen index > 4 respectively), oligomenorrhea or amenorrhea and polycystic ovaries on transvaginal ultrasound. These women therefore represented the phenotype with the greatest metabolic features.