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. 2017 Jun 15;7:3572. doi: 10.1038/s41598-017-03913-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transplantation of LEA29Y-tg neonatal porcine islet-like clusters (NPICCs) into diabetic NSG mice carrying a human immune system (HU-SRC-SCID). (A) Development of normoglycemia (random blood glucose levels consistently <120 mg/dl), blood glucose (C) response and insulin secretion (D) during intraperitoneal glucose tolerance testing was comparable in humanized Tx-LEA-tg and immunodeficient NSG mice transplanted with equivalent numbers of NPICCs. The 125-day time course of mice with LEA-tg NPICCs shows normalization of blood glucose levels in n = 5 mice, near normal glucose levels in n = 2 animals, and persistent hyperglycemia in n = 1 mouse (B). In contrast, all Tx-wt remained hyperglycemic (Log-rank test p = 0.039) (A,B). N = number of animals examined per group.