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. 2017 Jun 15;7:3572. doi: 10.1038/s41598-017-03913-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Long-term preservation of beta cell function in HU-SRC-SCID mice transplanted with LEA29Y expressing NPICCs. Xenograft was harvested 29 weeks post transplantation and stained for (A) human CD45 (brown) and insulin (red), (B) glucagon (brown) and (C) somatostatin (brown). Local LEA29Y expression preserved ICC structure and restricted human immune infiltration to the periphery of the transplantation site. Scale bar: 100 μm.