Table 1.

NMR Data for Neo-actinomycin A (1) in DMSO-d ₆ ^a _. ^a1H and ¹³C NMR data were recorded at 600 and 150 MHz, respectively.

no.	pentapeptidolactone (α-ring)		no.	pentapeptidolactone (β-ring)
	δ H, m (J in Hz)	δ C, type		δ H, m (J in Hz)	δ C, type
Thr 1		169.2, C	Thr 1		169.4, C
2	4.97, dd (9.0, 2.4)	53.9, CH	2	4.84, dd (8.4, 2.4)	54.9, CH
3	5.14, qd (6.0, 2.4)	72.3, CH	3	5.24, qd (6.0, 2.4)	71.9, CH
4	1.17, d (6.0)	16.3, CH3	4	1.20, d (6.0)	16.7, CH3
NH	7.25, d (9.0)		NH	9.66, d (8.4)
Val 1		170.6, C	Val 1		170.7, C
2	3.50, m	57.4, CH	2	3.49, m	57.4, CH
3	1.88, m	30.1, CH	3	1.88, m	30.2, CH
4	0.92, d (6.6)	18.6, CH3	4	0.94, d (6.6)	18.6, CH3
5	0.69, d (7.2)	19.1, CH3	5	0.70, d (7.2)	19.1, CH3
NH	8.42, d (6.0)		NH	8.29, d (5.4)
Pro 1		173.0, C	Pro 1		173.0, C
2	6.24, dd (9.0,3.0)	54.8, CH	2	6.21, dd (9.0,3.0)	54.8, CH
3	2.10, m; 1.74, m	31.1, CH2	3	2.10, m; 1.74, m	31.2, CH2
4	1.91, m; 1.67, m	22.7, CH2	4	1.91, m; 1.67, m	22.8, CH2
5	3.49, m; 3.27, m	46.4, CH2	5	3.50, m; 3.27, m	46.4, CH2
Sar 1		167.0, C	Sar 1		167.1, C
2	4.80, d (18.0); 4.08, d (18.0)	51.2, CH2	2	4.78, d (18.0); 4.08, d (18.0)	51.2, CH2
NMe	2.75, s	34.4, CH3	NMe	2.75, s	34.4, CH3
MeVal 1		168.1, C	MeVal 1		168.2, C
2	3.23, d (9.6)	69.5, CH	2	3.23, d (9.6)	69.6, CH
3	2.54, m	26.5, CH	3	2.54, m	26.5, CH
4	0.97, d (6.6)	21.0, CH3	4	0.98, d (6.6)	21.1, CH3
5	0.79, d (6.6)	18.8, CH3	5	0.80, d (6.6)	18.8, CH3
NMe	3.19, s	38.6, CH3	NMe	3.19, s	38.8, CH3
chromophore
2		165.8, C	10a		139.5, C
3a		132.9, C	11		111.8, C
4		100.2, C	11a		143.5, C
4a		132.0, C	12	2.13, s	14.8, CH3
5	11.74, s		13	2.27, s	8.9, CH3
5a		131.3, C	14		166.6, C
6		113.4, C	15		165.4, C
7	7.11, d (8.4)	122.0, CH	16	3.17, m	23.3, CH2
8	6.62, d (8.4)	122.0, CH	17	2.89, m	30.3, CH2
9		127.5, C	18		173.1, C
9a		140.7, C