Table 2.
Antimicrobial Bioassay Results (MIC, μg/mL) for compounds 1–4. aMethicillin-susceptible Staphylococcus aureus. bMethicillin-resistant S. aureus. cMethicillin-susceptible S. epidermidis. dMethicillin-resistant S. epidermidis. eVancomycin-susceptible Enterococcus. fVancomycin-resistant Enterococcus. gExtended-spectrum beta-lactamase-producing strain. hNew Delhi metallo-beta-lactamase 1.
| microorganism | strain no. | phenotype | 1 | 2 | 3 | 4 | levofloxacin |
|---|---|---|---|---|---|---|---|
| Staphylococcus aureus | ATCC 29213 | MSSAa | 16 | >128 | 0.25 | 0.25 | 0.125 |
| Staphylococcus aureus | 15 | MSSA | 32 | >128 | 0.25 | 0.125 | 0.125 |
| Staphylococcus aureus | 13–17 | MSSA | 32 | >128 | 0.25 | 0.125 | 0.125 |
| Staphylococcus aureus | ATCC 33591 | MRSAb | 16 | >128 | 0.25 | 0.25 | 0.125 |
| Staphylococcus aureus | 13–18 | MRSA | 64 | >128 | 0.25 | 0.25 | 32 |
| Staphylococcus epidermidis | ATCC 12228 | MSSEc | 64 | >128 | 0.5 | 0.25 | 0.125 |
| Staphylococcus epidermidis | 13–1 | MSSE | 64 | >128 | 0.5 | 0.125 | 0.25 |
| Staphylococcus epidermidis | 13–3 | MRSEd | 32 | >128 | 0.5 | 0.25 | 64 |
| Enterococcus faecalis | ATCC 29212 | VSEe | 16 | >128 | 0.25 | 0.125 | 1 |
| Enterococcus faecalis | 13–4 | VSE | 16 | >128 | 0.25 | 0.06 | 1 |
| Enterococcus faecalis | ATCC 51299 | VREf | 16 | >128 | 0.25 | 0.125 | 1 |
| Enterococcus faecalis | ATCC 51575 | VRE | 16 | >128 | 0.25 | 0.25 | 1 |
| Enterococcus faecium | ATCC 700221 | VRE | 32 | >128 | 0.125 | 0.125 | 64 |
| Enterococcus faecium | 13–7 | VSE | 32 | >128 | 0.25 | 0.25 | 64 |
| Enterococcus faecium | 12–1 | VRE | 32 | >128 | 0.25 | 0.25 | 64 |
| Escherichia coli | ATCC 25922 | >128 | >128 | 64 | 128 | ≤0.03 | |
| Escherichia coli | 1515 | >128 | >128 | 64 | 128 | ≤0.03 | |
| Escherichia coli | 14–10 | >128 | >128 | 32 | 128 | 2 | |
| Escherichia coli | 14–11 | ESBLsg | >128 | >128 | 64 | 64 | 16 |
| Klebsiella pneumoniae | ATCC 700603 | ESBLs | >128 | >128 | >128 | >128 | 0.5 |
| Klebsiella pneumoniae | 7 | >128 | >128 | >128 | >128 | 0.06 | |
| Klebsiella pneumoniae | ATCC BAA-2146 | NDM-1h | >128 | >128 | 128 | 128 | >128 |
| Klebsiella pneumoniae | 14–4 | >128 | >128 | >128 | >128 | 0.125 | |
| Klebsiella pneumoniae | 14–15 | ESBLs | >128 | >128 | >128 | >128 | 0.25 |
| Pseudomonas aeruginosa | ATCC 27853 | >128 | >128 | >128 | >128 | 1 | |
| Pseudomonas aeruginosa | PAO1 | 128 | >128 | >128 | >128 | 4 | |
| Pseudomonas aeruginosa | 13–46 | >128 | >128 | >128 | >128 | 0.25 | |
| Acinetobacter calcoacetious | ATCC 19606 | >128 | >128 | 32 | 32 | 0.125 | |
| Enterobacter cloacae | ATCC 43560 | >128 | >128 | 32 | 16 | ≤0.03 | |
| Enterobacter aerogenes | ATCC 13048 | >128 | >128 | >128 | >128 | 0.125 | |
| Serratia marcescens | ATCC 21074 | >128 | >128 | >128 | >128 | 0.125 | |
| Morganella morganii | ATCC 25830 | >128 | >128 | 128 | >128 | 0.125 | |
| Providentia rettgeri | ATCC 31052 | >128 | >128 | >128 | >128 | ≤0.03 | |
| Proteus vulgaris | ATCC 29905 | >128 | >128 | >128 | >128 | ≤0.03 | |
| Proteus mirabilis | 13–1 | >128 | >128 | >128 | 128 | 0.125 | |
| Stenotrophomonas maltophilia | ATCC 13636 | >128 | >128 | 32 | 16 | 1 | |
| Citrobacter freundii | ATCC 43864 | >128 | >128 | >128 | >128 | 0.125 |