Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 15;7:3614. doi: 10.1038/s41598-017-03972-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

miR-200 overexpression in UCS xenograft tumor models. NSG mice were subcutaneously injected with miR-200c-overexpressed and control cells. (A) Tumor growth in control vs. 3 different miR-200c-overexpressed JHUCS-1 clones over 37 days (n = 4 per group). (B) JHUCS-1 and (C) SNU-685 tumor growth in mice bearing miR-200c-overexpressed vs. control cells over 60 and 67 days, respectively (n = 5 per group). Bar graphs depict relative miR-200c expression in xenografted tumors. All graphical data are reported as mean ± SD. **P ≤ 0.01, ***P ≤ 0.001; Student’s T-test for independent samples. (D) H&E staining of JHUCS-1 xenografted tumors. All images were taken at 100X magnification. Scale bar, 50 µm. Rows I, II and III represent different sections of tumor. All NTC were comprised of predominantly spindled cells. (E) IHC for ZEB1 (nuclear), E-cadherin (membranous) and vimentin (cytoplasmic). For tumors with complete loss of protein expression, staining of blood vessels and stromal cells served as internal positive controls. Rows represent increasing magnification from top to bottom.