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. 2017 Jun 15;7:3614. doi: 10.1038/s41598-017-03972-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Systemic miR-200c nanoliposome treatment decreases in vivo UCS tumor growth. (A) NSG mice bearing JHUCS-1 wild-type (WT) UCS tumors were injected with DOPC-Scramble or DOPC-miR-200c nanoliposomes twice weekly by tail vein injection, starting 7 days after subcutaneous cell implantation. (B) Relative intra-tumoral miR-200c expression measured by TaqMan RT-PCR. Tumors from mice treated with DOPC-miR200c nanoliposomes were harvested 24, 48 or 72 hours after treatment. Data are normalized to DOPC-Scramble. (C) Relative intra-tumoral EMT markers expression measured by TaqMan RT-PCR. Tumor samples were same as in (B). TaqMan probes for ZEB1, E-cadherin and Vimentin are shown on the bottom. (D) Tumor growth of mice treated with DOPC-Scramble or DOPC-miR200c nanoliposomes (n = 10 per group). Mean tumor size is represented by the black horizontal lines. Data are normalized to the mean Day 7 tumor size, and represented as fold-change in tumor growth. There were no statistically significant differences in tumor growth between DOPC-Scramble and DOPC-miR-200c treated groups on Day 7 or Day 17. **P ≤ 0.01; Student’s t-test for independent samples.