Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 15;7:3568. doi: 10.1038/s41598-017-03362-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

EZH2 inversely correlates with TIMP2 and indicates poor prognosis. (a) Representative images of immunohistochemistry analysis of EZH2 and TIMP2 in ovarian cancer tissues. EZH2 was expressed in the nucleus, while TIMP2 was expressed in the cytoplasm. Sample No. 174 has high EZH2 expression and low TIMP2 expression. Sample No. 338 has low EZH2 expression and high TIMP2 expression (scale bar, 50 μm). (b) Negative correlation between the percentage of EZH2-positive cells and the TIMP2 staining score in ovarian cancer tissues (Spearman’s correlation test). (c–e) Kaplan-Meier plots for overall survival in epithelial ovarian cancer patients. High EZH2 (c), low TIMP2 (d) or high EZH2 and simultaneous low TIMP2 (e) are associated with reduced overall survival. (f–h) Kaplan-Meier plots for progression-free survival in patients with epithelial ovarian cancer stratified by the expression status of EZH2 (f), TIMP2 (g), or both EZH2 and TIMP2 (h).