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. 2017 Jun 15;7:3568. doi: 10.1038/s41598-017-03362-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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EZH2 recruits DNMTs at the TIMP2 promoter. (a) Location of binding sites of primers for MSP and qRT-PCR following ChIP in the context of CpG islands at the TIMP2 promoter. TSS, Transcription start site. (b) qRT-PCR analysis of immunoprecipitated chromatin by EZH2 and H3K27me3 antibodies. IgG served as a negative control. (c) A2780 and (d) OV2008 cells were transfected with EZH2 overexpression plasmid or control followed by ChIP and qRT–PCR for the quantitative detection of EZH2, H3K27me3, DNMT1 and DNMT3a on the TIMP2 promoter. The results were normalized to the input. *P < 0.05; **P < 0.01; ***P < 0.001. NS, not significant.