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. 2017 Jun 15;7:3584. doi: 10.1038/s41598-017-03616-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analyses of angiogenic activities in synovial tissues. (A) Few vessels (arrows) were developed within collagenase-injured joints in the miR-29aTg mice. (B) Synovial tissues in the miR-29aTg mice displayed minor response to collagenase escalation of VEGF and HIF-1α immunostaining. (C) miR-29a overexpression reduced the number of synovial fibroblasts positive for VEGF and HIF-1α. (D) miR-29a reduced the collagenase elevation of VEGF, VEGF-R1, VEGF-R2, and SDF-1 expression in synovial tissues. Each bar plot stands for mean ± standard error calculated from 8 animals in each group and analyzed by a parametric analysis of variance (ANOVA) and a Bonferroni post-hoc test. Asterisks (*) stands for significant difference between groups.