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. 2017 Jun 15;7:3584. doi: 10.1038/s41598-017-03616-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cartilage morphology and gait characteristics of collagenase-affected joints in miR-29aTg mice and wild-type mice. (A) Articular chondrocytes in the miR-29aTg mice displayed weak MMP13 mRNA expression and immunostaining (arrows) in knee joints. (B) Injured knees in the miR-29aTg mice showed smooth articular cartilage morphology (arrows) and intense Safarin O staining in association with (C) lower OARSI scores than those of the wild-type mice. (D) The miR-29aTg mice showed regular footprint histograms in the collagenase-injected knees. The miR-29aTg mice exhibited minor response to the collagenase disturbance of (E) print area, maximum contact area, contact intensity, maximum intensity affected joints. (F) The collagenase disturbance of wing speed, swing time, and stand time were lessened in the miR-29aTg mice. Each bar plot stands for mean ± standard error calculated from 8 animals in each group and analyzed by a parametric analysis of variance (ANOVA) and a Bonferroni post-hoc test. Asterisks (*) stands for significant difference between groups.