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. 2017 Jun 9;8:15754. doi: 10.1038/ncomms15754

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Copyright © 2017, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Intra-mitochondrial Ca²⁺ flux triggers mitoBK_Ca-mediated mitochondrial bulging and depolarization. Synergistically, stabilized Oma1 cleaves L-Opa1 resulting accumulation of S-Opa1, which neutralizes Mic60-mediated OMM–IBM tethering. This CoMIC contributes to Drp1-mediated mitochondrial division.