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. 2017 Jun 8;8:15594. doi: 10.1038/ncomms15594

Figure 5. In vivo magnetic targeting.

Figure 5

(a) Set-up of the in vivo experiment. An athymic nude mouse was anaesthetized with isoflurane with one of its lateral tail veins aligned with the edge of a rare-earth magnet. (b) A schematic diagram of the mouse tail and the magnet. (c) Simulated distributions of magnetic flux density and magnetic force. The circle represents the lateral tail vein near the magnet. (d) Simulated concentration profiles of MNPs of different sizes on the vessel wall close to the edge of the block magnet. Dashed lines mark the ends of the block magnet. Fluctuations in the concentration are caused by the interpolation of numerical results. (e) Simulated concentration profile of 33 nm MNPs in the cross-section of the lateral tail vein. (f) Magnetic targeting of 33 nm MNPs labelled with DiR. The dashed box marks the segment of the tail next to the magnet. The NIR fluorescence signal (ex/em=710 nm/780 nm) was pseudocoloured as indicated with the colour bar. Accumulation of MNPs increased along the blood flow direction from the distal to the proximal end of the tail. Scale bar, 10 mm. (g) MNPs in the mouse tails quantified by a superconducting quantum interference device (SQUID; mean±s.d.; n=3; *P<0.05).