TABLE 1.
Microdilution MICs of dalbavancin compared to those of other agents
| Drug | MIC (μg/ml) of drug for strain groupa
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
S. aureus
|
Coagulase-negative staphylococci
|
|||||||||||
| Methicillin S (43)
|
Methicillin R (29)
|
Methicillin S (38)
|
Methicillin R (36)
|
|||||||||
| Range | 50% | 90% | Range | 50% | 90% | Range | 50% | 90% | Range | 50% | 90% | |
| Dalbavancin | ≤0.015-0.125 | 0.06 | 0.06 | ≤0.015-0.125 | 0.03 | 0.06 | ≤0.015-0.06 | 0.03 | 0.06 | ≤0.015-0.25 | 0.03 | 0.06 |
| Vancomyin | 0.5-1.0 | 0.5 | 1.0 | 0.25-2.0 | 0.5 | 1.0 | 0.5-2.0 | 1.0 | 2.0 | 1.0-2.0 | 2.0 | 2.0 |
| Teicoplanin | 0.125-2.0 | 0.5 | 1.0 | 0.125-1.0 | 0.5 | 1.0 | 0.25-16 | 1.0 | 8.0 | 0.5->16.0 | 4.0 | 16.0 |
| Linezolid | 1.0-4.0 | 2.0 | 4.0 | 1.0-4.0 | 2.0 | 4.0 | 1.0-4.0 | 1.0 | 2.0 | 1.0-2.0 | 1.0 | 2.0 |
| Ranbezolid | ≤0.06-2.0 | 1.0 | 2.0 | 0.5-4.0 | 2.0 | 4.0 | ≤0.06-1.0 | 0.125 | 0.5 | ≤0.06-4.0 | 0.25 | 1.0 |
| Oritavancin | 0.25-4.0 | 2.0 | 2.0 | 0.25-4.0 | 2.0 | 2.0 | 0.5-2.0 | 2.0 | 2.0 | 1.0-4.0 | 2.0 | 4.0 |
| Daptomycin | 0.125-0.5 | 0.25 | 0.5 | 0.125-0.5 | 0.5 | 0.5 | 0.125-1.0 | 0.5 | 0.5 | 0.25-1.0 | 0.5 | 0.5 |
| Quinu/Dalfob | 0.125-0.5 | 0.25 | 0.5 | 0.125-1.0 | 0.5 | 0.5 | ≤0.06-1.0 | 0.125 | 0.5 | 0.125-1.0 | 0.125 | 0.5 |
a
S, sensitive; R, resistant. Number of strains is given in parentheses.
b
Quinupristin-dalfopristin.