TABLE 3.
Time-kill results
| Drug or concn | No. of strains with Δlog10 CFU/mla at:
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 h
|
6 h
|
12 h
|
24 h
|
|||||||||
| −1 | −2 | −3 | −1 | −2 | −3 | −1 | −2 | −3 | −1 | −2 | −3 | |
| Dalbavancin | ||||||||||||
| 4× MIC | 0 | 0 | 0 | 6 | 0 | 0 | 6 | 6 | 0 | 6 | 6 | 6 |
| 2× MIC | 0 | 0 | 0 | 5 | 0 | 0 | 6 | 4 | 0 | 6 | 5 | 3 |
| MIC | 0 | 0 | 0 | 4 | 0 | 0 | 6 | 4 | 0 | 3 | 3 | 2 |
| Vancomycin | ||||||||||||
| 4× MIC | 1 | 0 | 0 | 5 | 0 | 0 | 6 | 5 | 1 | 6 | 5 | 4 |
| 2× MIC | 1 | 0 | 0 | 5 | 0 | 0 | 6 | 5 | 1 | 6 | 5 | 4 |
| MIC | 1 | 0 | 0 | 4 | 0 | 0 | 5 | 2 | 1 | 4 | 3 | 1 |
| Teicoplanin | ||||||||||||
| 4× MIC | 2 | 0 | 0 | 6 | 0 | 0 | 6 | 4 | 0 | 6 | 6 | 4 |
| 2× MIC | 2 | 0 | 0 | 5 | 0 | 0 | 5 | 2 | 0 | 6 | 6 | 3 |
| MIC | 0 | 0 | 0 | 3 | 0 | 0 | 5 | 1 | 0 | 4 | 4 | 2 |
| Linezolid | ||||||||||||
| 4× MIC | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 |
| 2× MIC | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| MIC | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Ranbezolid | ||||||||||||
| 4× MIC | 0 | 0 | 0 | 1 | 1 | 0 | 2 | 0 | 0 | 6 | 0 | 0 |
| 2× MIC | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 5 | 0 | 0 |
| MIC | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 |
| Oritavancin | ||||||||||||
| 4× MIC | 6 | 6 | 3 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 | 6 |
| 2× MIC | 6 | 6 | 3 | 6 | 6 | 6 | 6 | 6 | 5 | 6 | 6 | 6 |
| MIC | 6 | 4 | 1 | 6 | 6 | 5 | 6 | 4 | 4 | 4 | 2 | 2 |
| Daptomycin | ||||||||||||
| 4× MIC | 6 | 4 | 4 | 6 | 6 | 4 | 6 | 6 | 6 | 6 | 6 | 6 |
| 2× MIC | 5 | 4 | 2 | 6 | 5 | 4 | 6 | 6 | 6 | 6 | 6 | 5 |
| MIC | 4 | 3 | 0 | 6 | 4 | 2 | 6 | 6 | 3 | 6 | 5 | 5 |
| Quinupristin/dalfopristin | ||||||||||||
| 4× MIC | 0 | 0 | 0 | 2 | 0 | 0 | 3 | 0 | 0 | 4 | 0 | 0 |
| 2× MIC | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 0 | 3 | 0 | 0 |
| MIC | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 0 |
a
−1, 90% killing; −2, 99% killing; −3, 99.9% killing.