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. 2017 Jun 16;7:246. doi: 10.3389/fcimb.2017.00246

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Copyright © 2017 Yu, Zhou, Guo, Ji, Niu, Xiao, Shen and Xiao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vitro dynamic model time-kill assays using concentrations of fosfomycin, amikacin, and colistin (either alone or in combination) against three KPC-producing K. pneumoniae strains. (A) and (B) mono or combination therapy, respectively, against isolate ATCC BAA-1705; (C) and (D) mono or combination therapy, respectively, against isolate 17186; (E) and (F) mono- and combination therapy, respectively, against isolate 18253. FM, fosfomycin; AMK, amikacin; COL, colistin. The dotted lines indicate monotherapy, and the solid lines indicate combination therapy. Antibiotic concentrations are denoted by different symbols.