Table 3.
Minimum inhibitory concentrations of fosfomycin, colistin, and amikacin against three KPC-producing K. pneumoniae strains after 24 h in pharmacokinetics simulation studies.
| Isolates | Dosage regimen | FM | AMK | COL |
|---|---|---|---|---|
| ATCC-1705 | FM (8 g q8h) | 1 | 64 | 0.5 |
| AMK (7.5 mg/kg qd) | 1 | 64 | 0.5 | |
| AMK (15 mg/kg qd) | 1 | 64 | 0.5 | |
| COL (75000 IU/kg q12h) | 1 | 64 | 32 | |
| FM (8 g q8h)/AMK (7.5 mg/kg qd) | 1 | 64 | 0.5 | |
| FM (8 g q8h)/AMK (7.5 mg/kg q12h | 512 | >512 | 0.5 | |
| FM (8 g q8h)/AMK (15 mg/kg qd) | 1 | 64 | 0.5 | |
| FM (8 g q8h)/COL (75000 IU/kg q12h) | 1 | 64 | 0.5 | |
| 17186 | FM (8 g q8h) | 8 | 1 | 0.25 |
| AMK (7.5 mg/kg qd) | 8 | 2 | 0.25 | |
| AMK (15 mg/kg qd) | 8 | 1 | 0.25 | |
| COL (75000 IU/kg q12h) | 16 | 1 | 8 | |
| FM (8 g q8h)/AMK (7.5 mg/kg qd | 8 | 1 | 0.25 | |
| FM (8 g q8h)/AMK (7.5 mg/kg q12h | 64 | >512 | 0.25 | |
| FM (8 g q8h)/AMK (15 mg/kg qd) | 8 | 1 | 0.25 | |
| FM (8 g q8h)/COL (75000 IU/kg q12h) | 8 | 1 | 0.25 | |
| 18253 | FM (8 g q8h) | 16 | 4 | >32 |
| AMK (7.5 mg/kg qd) | 16 | 4 | >32 | |
| AMK (15 mg/kg qd) | 16 | 4 | >32 | |
| COL (75000 IU/kg q12h) | 16 | 4 | >32 | |
| FM (8 g q8h)/AMK (7.5 mg/kg qd | 16 | 4 | >32 | |
| FM (8 g q8h)/AMK (7.5 mg/kg q12h | 512 | >512 | >32 | |
| FM (8 g q8h)/AMK (15 mg/kg qd) | 16 | 4 | >32 | |
| FM (8 g q8h)/COL (75000 IU/kg q12h) | 16 | 4 | >32 |
FM, fosfomycin; COL, colistin; AMK, amikacin.