TABLE 1.
Pharmacokinetics of tenofovir
| Study day and statisticsa | AUC0-24 (mg · h/liter) | Cmax (mg/liter) | Cmin (mg/liter) | Tmax (h)c | t1/2 (h) | CL/F |
|---|---|---|---|---|---|---|
| Day 10 | 3.56 ± 0.77 (3.48)b | 0.36 ± 0.080 (0.36) | 0.071 ± 0.016 (0.069) | 1.0 (1.0-3.0) | 13.8 ± 4.53 (13.2) | 88.1 ± 19.0 (86.2) |
| Day 20 | 3.11 ± 0.57 (3.06) | 0.30 ± 0.060 (0.30) | 0.060 ± 0.011 (0.059) | 1.0 (1.0-2.0) | 11.6 ± 2.77 (11.2) | 99.8 ± 20.3 (98.0) |
| Geometric mean ratio for day 20/day 10 (90% CI) | 0.88 (0.84-0.92) | 0.84 (0.78-0.90) | 0.85 (0.80-0.91) |
a
n = 23. CI, confidence interval.
b
Values are arithmetic means ± standard deviations (geometric means), unless indicated otherwise.
c
Values are medians (ranges).