Table 2. Mean (and standard deviation) of laboratory values.
Laboratory test | Baseline | 4 Weeks | EOT | SVR12 | Pt Diff | p-Value* |
Platelet count (×1000 cells/μL) | 143.4 ± 59.1 | 160.1 ± 65.6 | 159.9 ± 76.1 | 152.6 ± 67.5 | 9.2 (9.2) | 0.054 |
Albumin (g/dL) | 4.1 ± 1.2 | 4.1 ± 0.4 | 4.1 ± 0.4 | 4.1 ± 0.5 | 0 (0) | 0.822 |
AST (U/L) | 62.4 ± 79.5 | 25.0 ± 13.9 | 25.6 ± 20.3 | 28.2 ± 22.3 | −34.3 (−34.3) | <0.001 |
ALT (U/L) | 76.8 ± 126 | 25.2 ± 19.2 | 24.6 ± 21.7 | 27.6 ± 24.5 | −49.3 (−49.3) | 0.001 |
Total bilirubin (mg/dL) | 0.8 ± 1.3 | 0.9 ± 0.7 | 0.9 ± 1.2 | 0.7 ± 0.9 | −0.1 (−0.1) | 0.453 |
Serum creatinine (mg/dL)† | 1.3 ± 0.4 | 1.3 ± 0.4 | 1.3 ± 0.4 | 1.3 ± 0.4 | 0 (0) | 0.514 |
Alkaline phosphatase (U/L) | 129.5 ± 175.3 | 111.4 ± 176.7 | 99.6 ± 53.6 | 124.2 ± 134.7 | −5.3 (−5.3) | 0.694 |
Hemoglobin (g/dL) | 12.8 ± 1.7 | 11.9 ± 2.3 | 12.0 ± 2.1 | 13.2 ± 1.8 | 0.3 (0.3) | 0.033 |
In patients with RBV therapy | 13.2 ± 1.3 | 11.5 ± 2.1 | 12.0 ± 1.7 | 13.4 ± 1.6 | 0.2 (0.2) | 0.477 |
In patients without RBV therapy | 12.5 ± 2.0 | 12.3 ± 2.5 | 12.1 ± 2.5 | 13.0 ± 2.0 | 0.5 (0.5) | 0.017 |
Abbreviations: EOT, end of treatment; SVR12, sustained viral response at 12 weeks; AST, aspartate transaminase; ALT, alanine transaminase; Pt Diff, point difference.
Baseline vs. SVR12 paired t-test.
Patients on dialysis were not included in the calculation of mean and standard deviation for serum creatinine.