Table 1.
Serum-VEGF, serum-bFGF and urinary-bFGF levels at diagnosis, according to patient and tumour characteristics
| Serum VEGF (pg/mL) | Serum bFGF (pg/mL) | Urinary bFGF (ng/g creatinine) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| N | Median [Q1-Q3]a | P value b | N | Median [Q1-Q3]a | P value b | N | Median [Q1-Q3]a | P value b | |
| All | 246 | 428 [274–685] | 242 | 4.3 [3–13] | 129 | 5.2 [2.7–10.4] | |||
| Gender | 0.94 | 0.10 | 0.30 | ||||||
| Male | 136 | 432 [286–675] | 133 | 5 [3–14] | 70 | 4.5 [2.4–9.6] | |||
| Female | 110 | 427 [252–686] | 109 | 4 [3–11] | 59 | 5.6 [3.1–10.9] | |||
| Age | 0.65 | 0.07 | 0.03 | ||||||
| < 13 years | 71 | 466 [223–692] | 71 | 7 [3–18] | 36 | 7.5 [4.8–12.9] | |||
| 13–18 years | 106 | 399 [271–686] | 104 | 4 [3–13] | 59 | 4.1 [2.2–8.9] | |||
| > 18 years | 69 | 440 [327–642] | 67 | 3 [3–10] | 34 | 5.3 [1.9–11.4] | |||
| Tumour size | 0.003 | 0.24 | 0.28 | ||||||
| < 10 cm | 110 | 391 [222–567] | 108 | 5 [3–12] | 59 | 4.9 [2.1–9.6] | |||
| ≥ 10 cm | 121 | 504 [308–738] | 119 | 3 [3–13] | 62 | 5.3 [2.9–11.6] | |||
| Initial stage c | 0.64 | 0.16 | 0.17 | ||||||
| Localized | 164 | 431 [258–689] | 162 | 4 [3–11] | 92 | 5176 [2.4–9.2] | |||
| Doubtful lesions | 40 | 418 [335–711] | 39 | 7 [3–15] | 21 | 4.9 [3.3–12.2] | |||
| Metastases | 39 | 396 [274–621] | 38 | 3 [3–7] | 15 | 9.6 [3.5–17.1] | |||
| Histologic subtype | 0.36 | 0.57 | 0.46 | ||||||
| Osteoblastic | 154 | 435 [303–735] | 152 | 5 [3–13] | 82 | 5.3 [2.8–10.8] | |||
| Fibroblastic | 10 | 399 [205–512] | 11 | 7 [3–13] | 2 | 2.6 [1.8–3.3] | |||
| Chondroblastic | 40 | 461 [280–610] | 38 | 4 [3–11] | 26 | 5.5 [3.5–11.4] | |||
| Telangiectasic | 7 | 283 [178–692] | 7 | 3 [3–3] | 4 | 5.3 [4–77.3] | |||
| Other | 25 | 365 [241–484] | 24 | 4 [3–14] | 13 | 3.1 [1.8–7.9] | |||
| Alkaline phosphatase | 0.11 | 0.21 | 0.33 | ||||||
| < 1.25 x ULN | 137 | 404 [252–644] | 135 | 5 [3–11] | 74 | 4.9 [2.5–9.6] | |||
| ≥ 1.25 x ULN | 70 | 472 [305–736] | 69 | 3 [3–13] | 40 | 6.1 [3–13.6] | |||
| Histological response d | 0.92 | 0.40 | 0.44 | ||||||
| Good | 138 | 435 [283–732] | 137 | 5 [3–13] | 85 | 5.1 [2.9–10.2] | |||
| Poor | 76 | 429 [314–647] | 74 | 4 [3–11] | 31 | 4.1 [2.1–8.9] | |||
a[Q1-Q3]: inter-quartile range
bKruskal-Wallis test comparing the distributions between the different subsets
cLung metastases on CT were defined by ≥1 nodule >10 mm, and/or ≥2 nodules from 5 to 9 mm, and/or ≥5 well limited nodules <5 mm. Other types of lesion were considered as doubtful lesions
dResults by quartile of the distributions are available in Additional file 5 Table-S3