Table 1. Phenotype comparison of Ppp6c knockout and Ppp6r1 (SAPS1) knockout mice models [46 and unpublished data].
| PP6c KO | SAPS1 KO | |
|---|---|---|
| Targeted gene | Pppc6 | Ppp6r1 (SAPS1) |
| Chromosome location | Chromosome 2 | Chromosome 7 |
| Cre recombinase | Lck-Cre, CD4-Cre | Sox2-Cre |
| Splenic IL-4+CD4+ T cells (%)1 | Up | Up |
| Splenic CD8+IL-4+ T cells (%)1 | Up | No difference |
| Splenic CD8+INFγ+ T cells (%)1 | Up | No difference |
| Phospho-p65/RelA | Up2 | Up3 |
Following methods were used to measure the parameters: 1 Flow cytometry; 2immunoblot; 3RPPA.