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. Author manuscript; available in PMC: 2018 May 15.
Published in final edited form as: J Immunol. 2017 Apr 5;198(10):3815–3822. doi: 10.4049/jimmunol.1700014

Fig. 6. A tentative schematic diagram showing possible pathways eliciting the effect of gestational SS exposure.

Fig. 6

Desensitization of nAChRs during gestational nicotine/SS-exposure affects HIF-1α levels increasing apoptosis and decreasing angiogenesis in the lung. The expression of pro-apoptotic miRs (miR-16 and miR-221) is significantly elevated in gestationally SS-exposed. Gestational SS-exposure decreases miR-130a that targets the anti-angiogenic factor GAX and the proapoptotic factor RUNX3 (both GAX and RUNX3 are increased in F1 and F2 lungs). Red arrows indicate established responses with upward arrows indicating significant increase and downward arrows indicating significant decrease in the indicated response. Components in the pathway that are without the arrows predict the indicated response but remain hitherto unproven.