Table 3.

Vasculogenesis mediators, molecules involved and their role in course of vasculogenesis

Vasculogensis mediators	Molecules invloved	Role
I) Cell-cell mediators	VE-cadherin N-cadherin claudin connexins (Cx37, Cx40, and CX43) occludin zonula occludens molecules (ZO-1, ZO-2, ZO-3)	cellular communication
II) Cell-matrix mediators	integrins (αvβ3, αvβ5, α4β1) thrombospondin 1 and 2 (Tsp1 and Tsp2)	cell survical cell migration apoptosis inhibition promoting vasculogenesis (integrins) blocking vasculogenesis (Tsp)
III) Signaling mediators	SDF-1 (CXCL12)/CXCR4 signaling vascular endothelial growth factor signaling (VEGF) Tie2/Ang1 signaling hedgehog Notch signaling wingless (Wnt)/β-cadherine signaling	promoting and supporting vasculogenesis cellular regulation cellular proliferation and differentiation cellular fate determination