Table 4.

Factors that contributed to maintaining Child-Pugh scores at 4 weeks

	n	Maintaining Child-Pugh scores, %	Univariate p valuea	Hazard ratio (95% CI)	Multivariate p valueb
Age
≥69 years	97	66.0	0.83
<69 years	86	67.4
Gender
Male	149	66.4	0.89
Female	34	67.6
ECOG performance status
0	169	68.0	0.17
1–3	14	50.0
Hepatitis B virus surface antigen
Positive	51	70.6	0.48
Negative	132	65.2
Hepatitis C virus antibody
Positive	94	64.9	0.60
Negative	89	68.5
Child-Pugh score
6	91	73.9	0.037	1.898 (0.996–3.610)	0.052
5	92	59.3
Branched-chain amino acid
Positive	28	57.1	0.25
Negative	155	68.4
Maximum tumor size
<50 mm	126	67.5	0.73
≥50 mm	57	64.9
Number of tumors
<6	54	64.8	0.73
≥6	129	67.4
Vascular invasion
Negative	110	69.1	0.39
Positive	73	63.0
Extrahepatic lesion
Negative	139	71.2	0.020	1.861 (0.883–3.923)	0.10
Positive	44	52.2
AFP
<400 ng/mL	116	69.0	0.39
≥400 ng/mL	67	62.7
Treatment
HAIC	137	72.3	0.0056	2.119 (1.021–4.399)	0.044
Sorafenib	46	50.0
Best response to treatmentc
Complete response, partial response, or stable disease	119	69.7	0.23
Progressive disease or not evaluable	64	60.9

AFP, α-fetoprotein; HAIC, hepatic arterial infusion chemotherapy; ECOG, Eastern Cooperative Oncology Group.

^alog-rank test.

^bCox proportional hazards regression model.

^cBased on RECIST v1.1.