Table 2.

Urinary level of furan metabolite in urine from furan-treated rodents (nmol/mg creatinine)

	BDA-Lysine Metabolites		N-Acetylcysteine-BDA-Lysine Metabolites
Species and exposure	6	1	2	3	4	5
Rata
0 mg/kg (n = 2)	<0.0004b	0.8,0.3	ND,c 0.012	<0.001, <0.001	ND, 0.0003	0.001, 0.0003
8 mg/kg (n = 2)	<0.0004	1.2, 1.1	0.080, 0.066	0.005, 0.004	0.07, 0.06	0.21, 0.19
40 mg/kg (n = 2)	<0.0004	11.7, 9.3	1.1, 0.71	0.054, 0.047	1.2, 0.69	3.5, 2.2
Mousea
0 mg/kg (n = 1)	<0.0004	0.2	0.2	0.02	<0.0002	0.001
8 mg/kg (n = 2)	<0.0004	2.2, 1.6	13.9, 11.5	2.8,5.5	0.001, 0.001	0.18, 0.33

^aMale F344 rats received 0, 8 or 40 mg/kg furan by gavage. Urine from individual animals was collected for 24 h.

^bLimits of quantitation

^cND = not determined.

^dGroups of 5 female B6C3F1 mice received 0 or 8 mg/kg furan by gavage and pooled urine was collected from each group for 24 h.