Table 1.

Stability of pyridyloxobutyl DNA adducts

DNA adduct	Conditions	product	reference
O6-pobdGuo	pH 7, 30 min at 100° C	Stable	54
	0.1 N HCl, 30 min at 80° C	O6-pobGua	54
	0.8 N HCl, 1 h at 80° C	HPB and Gua	54
7-pobdGuo	Enzyme hydrolysis of DNA: pH 7, 70 min at 37° C	Stable	55
	pH 7, 1 h at 100° C	7-pobGua and HPB	55
	0.1 N HCl, 1 h at 80° C	7-pobGua and HPB	55
O2-pobdCyd	Enzyme hydrolysis of DNA: pH 7, 70 min at 37° C	Stable	56
	pH 7, 1 h at 100° C	O2-pobCyt and HPB	56
O2-pobdThd	Enzyme hydrolysis of DNA: pH 7, 70 min at 37° C	Stable	56
	pH 7, 1 h at 100° C	Stable	56
	0.1 N HCl, 1 h at 85° C	O2-pobThy	56
Phosphate adducts	pH 7, 48 h at 37° C	Stable	58