. 2017 Jun 14;37(24):5834–5845. doi: 10.1523/JNEUROSCI.3680-16.2017

Table 1.

Arterial PCO₂, PO₂ and mean arterial pressure during baseline, the first hypoxic episode, and 60 min following AIH in end-stage SOD1^G93A rats and wild-type littermates

Experimental groups	P_aCO2 (mmHg)			P_aO2 (mmHg)			Mean arterial pressure (mmHg)
Experimental groups	Baseline	Hypoxia	60 min	Baseline	Hypoxia	60 min	Baseline	Hypoxia	60 min
With AIH
siNT
Wild-type	52.5 ± 1.5	52.6 ± 1.6	52.5 ± 1.8	325 ± 5^a,b,f	40.7 ± 1.0^g	296 ± 19^a,f	116 ± 9^a	75 ± 8^f,g	111 ± 8^a,f
SOD1^G93A	51.0 ± 1.8^a	52.5 ± 2.0	51.5 ± 1.5	334 ± 8^a	42.6 ± 2.2^h	325 ± 9^a	98 ± 7^a	71 ± 6^h	95 ± 7^a
siBDNF
Wild-type	52.5 ± 1.6	51.7 ± 1.8	53.0 ± 1.7^a	313 ± 9^a,f	38.8 ± 0.8^g	304 ± 7^a,f	112 ± 6^a,b	65 ± 4^g	99 ± 6^a
SOD1^G93A	51.2 ± 0.6	50.8 ± 0.7	51.2 ± 0.9	329 ± 4^a	40.5 ± 0.6^h	316 ± 7^a	112 ± 8^a	71 ± 7^h	100 ± 8^a
siTrkB
Wild-type	54.1 ± 1.7	54.3 ± 1.6	54.5 ± 1.8	299 ± 20^a,f	37.5 ± 1.0^g	285 ± 20^a,f	117 ± 4^a	72 ± 4^f,g	108 ± 4^a
SOD1^G93A	52.8 ± 1.5	52.4 ± 1.4	52.7 ± 1.9	318 ± 8^a	38.1 ± 1.4^h	290 ± 13^a	92 ± 21^a,b	67 ± 12^h	85 ± 12^a
Vehicle
Wild-type	50.9 ± 1.5^a	49.7 ± 1.5^d	51.3 ± 1.5^a	292 ± 9^a,f	37.4 ± 1.3^g	267 ± 15^a,f	98 ± 6^a,d	58 ± 8^g,j	92 ± 6^a,d,j
SOD1^G93A	50.6 ± 1.8	50.7 ± 1.8	50.9 ± 2.0	308 ± 12^a	36.6 ± 1.2^h	293 ± 15^a	97 ± 4^a,b,h	56 ± 5^h	77 ± 5^a,h,i
UO126
Wild-type	48.8 ± 1.0^d	48.5 ± 1.3^d	49.0 ± 1.0^d	303 ± 8^a,b,f	37.1 ± 2^g	272 ± 18^a,f	99 ± 5^a,b,d	70 ± 11^f,g	84 ± 3^a,d,j
SOD1^G93A	49.9 ± 1.4	49.4 ± 1.5	49.7 ± 1.3	285 ± 16^a,e	39.2 ± 1.9^h	271 ± 16^a,e	97 ± 3^a,b	53 ± 5^h	78 ± 8^a,h,i
PI828
Wild-type	51.4 ± 1.2^a	49.9 ± 1.4^d	51.2 ± 1.0^a	230 ± 21^a	36.8 ± 1.3^g	220 ± 19^a,g	106 ± 4^a,b	50 ± 4^g	88 ± 3^a,d
SOD1^G93A	51.6 ± 2.0	51.2 ± 1.8	52.2 ± 2.1^a	292 ± 20^a,b,f	38.3 ± 1.5^h	256 ± 25^a,e,f,h,i	94 ± 5^a,b	54 ± 4^h	82 ± 4^a
Without AIH (TCs)
Wild-type	50.0 ± 0.9	49.9 ± 1.0^d	50.2 ± 0.8^d	297 ± 14^f	295 ± 15	282 ± 17	105 ± 4	104 ± 4	98 ± 4^c
SOD1^G93A	49.7 ± 1.4	49.7 ± 1.6	48.8 ± 1.5^a,c	316 ± 8	305 ± 13	299 ± 10	112 ± 5^a,b	108 ± 5	95 ± 4

Data are for rats with AIH or without AIH. Rats received intrathecal injections of either (1) siRNAs targeting BDNF (siBDNF), TrkB (siTrkB), or nontarget (siNT) mRNA; or (2) vehicle or inhibitors for MEK/ERK (UO126) or PI3K/Akt (PI828). Significant differences within individual study groups are indicated as follows:

^asignificant difference from hypoxia,

^bsignificant difference from 60 min, and

^csignificant difference from baseline. Significant differences across study groups are indicated as follows:

^dsignificant difference from wild-type siTrkB,

^esignificant difference from SOD1^G93A siNT,

^fsignificant difference from wild-type PI828,

^gsignificant difference from wild-type without AIH,

^hsignificant difference from SOD1^G93A without AIH,

ⁱsignificant difference from SOD1^G93A siBDNF, and

^jsignificant difference from wild-type siNT. Values are expressed as means ± 1 SEM. Differences were considered significant if p < 0.05.