Figure 6.

Changes in select transcripts comprising the cancer signaling/proliferation super pathway. In contrast to the 34 differentially expressed transcripts comprising members of the “hereditary breast cancer,” “gadd45,” and “aryl hydrocarbon receptor” signaling pathways (19, 6, and 9 transcripts, respectively) seen in D3 livers, a total of eight pathways involving a total of 396 transcripts were deregulated in the super pathway in initial tumors. Most notably, these involved marked up-regulation of transcripts encoding ribosomal proteins (A), factors that facilitate mRNA engagement of and translation by the ribosome (B), and members of the mTOR pathway, which integrates a variety of growth-promoting signals and serves as a nutrient sensor (C) (57).