Figure 1.

Schematic representation of grafting into the SFTI-1 scaffold. The three-dimensional structure of annexin A1 is shown on the left of the diagram (PDB ID code 1HM6). MC-12, highlighted on the structure of annexin A1, forms a helical structure in the full-length protein. The helical region of MC-12 is schematically represented as grafted into the binding loop of SFTI-1. SFTI-1 comprises two β-strands connected by a disulfide bond. The cyclization loop is also labeled on the diagram. The figure was generated using MOLMOL (37).