TABLE 2.
In vitro susceptibility of 96 isolates of Aspergillus species to three antifungal agentsa
| Organism (no. of isolates) and agent | MIC (μg/ml)b
|
||
|---|---|---|---|
| Range | 50% | 90% | |
| A. fumigatus (40) | |||
| Ketoconazole | 0.06-8 | 2 | 4 |
| Itraconazole | 0.06-8 | 0.25 | 1 |
| Voriconazole | 0.06-0.5 | 0.25 | 0.5 |
| Amphotericin B | 0.25-2 | 0.5 | 1 |
| A. flavus (24) | |||
| Ketoconazole | 0.25-4 | 1 | 2 |
| Itraconazole | 0.06-8 | 0.5 | 1 |
| Voriconazole | 0.25-1 | 0.5 | 1 |
| Amphotericin B | 0.25-2 | 1 | 2 |
| A. niger (20) | |||
| Ketoconazole | 0.5-8 | 2 | 4 |
| Itraconazole | 0.5-2 | 0.5 | 2 |
| Voriconazole | 0.12-0.5 | 0.25 | 0.5 |
| Amphotericin B | 0.25-1 | 0.25 | 1 |
| A. terreus (12) | |||
| Ketoconazole | 0.5-2 | 1 | 1 |
| Itraconazole | 0.06-2 | 0.5 | 1 |
| Voriconazole | 0.25-1 | 0.5 | 1 |
| Amphotericin B | 0.06-1 | 1 | 1 |
| Aspergillus species (96) | |||
| Ketoconazole | 0.5-2 | 1 | 1 |
| Itraconazole | 0.06-8 | 0.5 | 1 |
| Voriconazole | 0.25-1 | 0.5 | 1 |
| Amphotericin B | 0.06-2 | 0.5 | 1 |
a
Data are from a program carried out in 2003 by the SMART study group. They were obtained by the broth microdilution method.
b
50% and 90%, MICs at which 50 and 90% of isolates are inhibited, respectively.