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. Author manuscript; available in PMC: 2017 Jun 16.
Published in final edited form as: J Med Chem. 2016 Apr 21;59(10):4511–4525. doi: 10.1021/acs.jmedchem.5b01762

Scheme 3. Synthesis of Analogues 9a–ja.

Scheme 3

aReagents and conditions: (a) 1,2,3-benzotriazole, AlCl3, THF, overnight; (b) MnO2, acetone, 55 °C, 24 h, 19–70% in two steps; (c) H2, Pd/C, methanol, 5 h, 57–87%.